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    • This is a Non-Federal dataset covered by different Terms of Use than Data.gov.

    RAD51 Interconnects Between DNA Replication DNA Repair and Immunity

    Metadata Updated: February 21, 2025

    RAD51 a multifunctional protein plays a central role in DNA replication and homologous recombination repair and is known to be involved in cancer development. We identified a novel role for RAD51 in innate immune response signaling. Defects in RAD51 lead to the accumulation of self-DNA in the cytoplasm triggering a STING-mediated innate immune response after replication stress and DNA damage. Our data suggest that in addition to playing roles in homologous recombination-mediated DNA double-strand break repair and replication fork processing RAD51 is also implicated in the suppression of innate immunity. Thus our study reveals a previously uncharacterized role of RAD51 in initiating immune signaling placing it at the hub of new interconnections between DNA replication DNA repair and immunity. Overall design Gene expression analysis of WT and sh RAD51 HT1080 cells was carried out before and after 1 Gy of high LET Fe particle radiation.

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    Public: This dataset is intended for public access and use. Non-Federal: This dataset is covered by different Terms of Use than Data.gov. License: No license information was provided.

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    Dates

    Metadata Created Date February 21, 2025
    Metadata Updated Date February 21, 2025
    Data Update Frequency irregular

    Metadata Source

    Harvested from nasa test json

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date February 21, 2025
    Metadata Updated Date February 21, 2025
    Publisher National Aeronautics and Space Administration
    Maintainer
    Identifier nasa_genelab_GLDS-130_xkj4-wfuy
    Data First Published 2018-06-26
    Data Last Modified 2025-02-19
    Category Earth Science
    Public Access Level public
    Data Update Frequency irregular
    Bureau Code 026:00
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Harvest Object Id 04ca3e9d-9492-4240-a6c6-b18619833bfc
    Harvest Source Id a73e0c30-4684-40ef-908e-d22e9e9e5f86
    Harvest Source Title nasa test json
    Homepage URL https://data.nasa.gov/d/xkj4-wfuy
    Program Code 026:005
    Source Datajson Identifier True
    Source Hash 7332c78cb63155345bca09894b940f152f0816f6d29eeb56a382befd52cb74be
    Source Schema Version 1.1

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