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    • This is a Non-Federal dataset covered by different Terms of Use than Data.gov.

    mRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under Microgravity

    Metadata Updated: February 21, 2025

    DLD-1 and MOLT-4 cell lines were cultured in a rotating cell culture system to simulate microgravity and mRNA expression profile in comparison to Static controls. Cells were grown in 10mL rotating vessels in a Rotary Cell Culture System (RCCS) and in 60mm Petri dishes (test control respectively). Two replicates of test (Microgravity) and control (static) each from DLD-1 and MOLT-4 were analyzed by microarray. Simulated microgravity affected the solid tumor cell line DLD-1 markedly which showed a higher percentage of dysregulated genes compared to the hematological tumor cell line MOLT-4. Microgravity affects the cell cycle of DLD-1 cells and disturbs expression of cell cycle regulatory gene networks. Multiple microRNA host genes were dysregulated and significantly mir-22 tumor suppressor microRNA is highly upregulated in DLD-1.

    Access & Use Information

    Public: This dataset is intended for public access and use. Non-Federal: This dataset is covered by different Terms of Use than Data.gov. License: us-pd

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    Dates

    Metadata Created Date February 21, 2025
    Metadata Updated Date February 21, 2025
    Data Update Frequency irregular

    Metadata Source

    Harvested from nasa test json

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date February 21, 2025
    Metadata Updated Date February 21, 2025
    Publisher National Aeronautics and Space Administration
    Maintainer
    Identifier nasa_genelab_GLDS-125_um5r-gqim
    Data First Published 2021-05-21
    Data Last Modified 2025-02-19
    Category Earth Science
    Public Access Level public
    Data Update Frequency irregular
    Bureau Code 026:00
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Harvest Object Id 2cba2ba4-b16f-45e5-8723-4d2323b73484
    Harvest Source Id a73e0c30-4684-40ef-908e-d22e9e9e5f86
    Harvest Source Title nasa test json
    Homepage URL https://data.nasa.gov/d/um5r-gqim
    License http://www.usa.gov/publicdomain/label/1.0/
    Program Code 026:005
    Source Datajson Identifier True
    Source Hash 59643b5688dddc49a02fbd0fba8fc2f9bafaeed333d4f9bc17ccfef31ff794f9
    Source Schema Version 1.1

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