Skip to main content
U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Skip to content
  • Feedback
    • This is a Non-Federal dataset covered by different Terms of Use than Data.gov.

    Effect of electromagnetic fields on the chondrogenic differentiation under microgravity conditions

    Metadata Updated: February 22, 2025

    A combination therapy of electromagnetic fields (EMF) and simulated microgravity (SMG) has not been examined in regenerative medicine of cartilage. In the present study a bioreactor system using extremely low-frequency EMF and SMG was applied during the chondrogenic differentiation of human mesenchymal stem cells (hMSCs). It was hypothesized that a beneficial effect of EMF regarding chondrogenesis (COL2A) could be combined with an avoiding effect of SMG regarding hypertrophy (COLXA1) of cartilage. Pellet cultures of hMSCs formed cartilaginous tissue under the addition of growth factors (FGF; TGF-beta3). Pure SMG reduced COLXA1 expression but also COL2A expression of hMSCs. Pure EMF showed no gene expression changes of hMSCs during chondrogenic differentiation. Combining EMF/SMG resulted in a re-increase of COL2A but did not reach control levels. The COL2A to COLXA1 ratio of combined EMF/SMG was not significantly different from control levels. The combination therapy of EMF/SMG did not significantly improve the chondrogenic potential of hMSCs. chondrogenic differentiation electromagnetic stimulation-control 1 timepoint with/without stimulation

    Access & Use Information

    Public: This dataset is intended for public access and use. Non-Federal: This dataset is covered by different Terms of Use than Data.gov. License: No license information was provided.

    Downloads & Resources

    Dates

    Metadata Created Date February 22, 2025
    Metadata Updated Date February 22, 2025
    Data Update Frequency irregular

    Metadata Source

    Harvested from nasa test json

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date February 22, 2025
    Metadata Updated Date February 22, 2025
    Publisher National Aeronautics and Space Administration
    Maintainer
    Identifier nasa_genelab_GLDS-124_jiw5-nq97
    Data First Published 2018-06-26
    Data Last Modified 2025-02-19
    Category Earth Science
    Public Access Level public
    Data Update Frequency irregular
    Bureau Code 026:00
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Harvest Object Id bca4f500-1c64-4ef1-9515-b8bea4db54f9
    Harvest Source Id a73e0c30-4684-40ef-908e-d22e9e9e5f86
    Harvest Source Title nasa test json
    Homepage URL https://data.nasa.gov/d/jiw5-nq97
    Program Code 026:005
    Source Datajson Identifier True
    Source Hash 39a992e6a0db97522d46f2ffd75a693dee92fcf206fc385b7f47179bca7de9a8
    Source Schema Version 1.1

    Didn't find what you're looking for? Suggest a dataset here.