Data Catalog

• Rodent Research-3-CASIS: Mouse adrenal gland transcriptomic proteomic and epigenomic data

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  The Rodent Research-3 (RR-3) mission was sponsored by the pharmaceutical company Eli Lilly and Co. and the Center for the Advancement of Science in Space to study the...

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• Biological Research in Canisters-16 (BRIC-16): Investigations of the plant cytoskeleton in microgravity with gene profiling and cytochemistry

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  These investigations studied the fundamentals of how plants perceive gravity and develop in microgravity. It informs how gene regulation is altered by spaceflight...

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• Transcription profiling of rat response to changes in developmental stage - 3 types of tissue 3 gravity conditions 2 developmental conditions

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  Transcriptional crosstalk between mammary gland liver and adipose tissue Experiment Overall Design: Pregnant and Lactating rats exposed to 3 gravity conditions

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• Gene-expression profiling of Saccharomyces cerevisiae irradiated by high-LET radiations

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  Ionizing radiations are categorized by linear energy transfer (LET) into low-LET and high-LET. High-LET is considered to have a higher relative biological...

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• Biological and Metabolic Response in STS-135 Space-flown Mouse Skin

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  Changes in gene expression profiles implicated in oxidative stress and in ECM remodeling in mouse skin were examined after space flight. The metabolic effects of space...

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• DNA copy number analysis from mice with radiation-induced acute myeloid leukemia

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  Certain mouse strains such as CBA C3H and RFM have high incidence of radiation-induced acute myeloid leukemia (AML). The data in this series wer generated by using...

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• Microgravity effect on C. elegans N2/VC (CERISE 4 days)

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  Microgravity effect on C. elegans gene expression was analysed by whole genome microarray. The worms were cultivated under microgravity for 4 days in the Japanese...

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• Effect of simulated microgravity on E. coli K12 MG1655 growth and gene expression

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  This study demonstrates simulated microgravity effects on E. coli K 12 MG1655 when grown on LB medium supplemented with glycerol. The results imply that E. coli...

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• Gene expression response to simulated gravity and hypergravity in human T cells

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  We investigated differentially regulated and stably expressed genes in human Jurkat T lymphocytic cells in 5min simulated microgravity and hypergravity and compared...

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• Dissecting Low Atmospheric Pressure Stress: Transcriptome Responses to the Components of Hypobaria in Arabidopsis [Experiment 1]

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  Controlled hypobaria presents biology with an environment that is never encountered in terrestrial ecology yet the apparent components of hypobaria are stresses...

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• Gene expression profiling in human fibroblast after low-LET irradiation

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  Exposure to radiation provokes cellular responses controlled in part by gene expression networks. MicroRNAs (miRNAs) are small non-coding RNAs which mostly regulate...

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• Root transcriptome remodeling of Arabidopsis in response to high levels of magnesium sulfate

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  Martian regolith (unconsolidated surface material) is a potential medium for plant growth in bioregenerative life support systems during manned missions on Mars....

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• Transcription profiling of Drosophila after exposure to microgravity in the International Space Station and in a microgravity simulator

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  Larvae-Pupae transition flies (Drosophila) were recovered and transport for 3 days at 12-14C to arrest development until the launch site then exposed to RT (18-20C)...

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• IMR90 radiation bystander time-course experiment 0.5Gy alpha particle

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  The radiation bystander effect is an important component of the overall biological response of tissues and organisms to ionizing radiation. Little is known about the...

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• Evaluation of in vitro macrophage differentiation during space flight

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  We differentiated mouse bone marrow cells in the presence of recombinant macrophage colony stimulating (rM-CSF) factor for 14 days during the flight of space shuttle...

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• Microarray Profile of Gene Expression during Osteoclast Differentiation in Modeled Microgravity

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  Microgravity leads to a 10-15% loss of bone mass in astronauts during space flight. Osteoclast is the multinucleated bone resorbing cell. In this study we used NASA...

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• Expression data from C. elegans

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  We used microarrays to investigate the effects of microgravity and space radiation on the genome-wide expression of the C. elegans. Three technical replicates of wild...

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• Bystander response to 2.5 Gy of protons in a human 3-dimensional skin model in 16 h after exposure

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  Bystander mechanisms that originate in the areas surrounding a tissue damage presumably play an important role participating in wound healing and tissue remodeling....

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• Comparison of gene expression profiles of normal human bronchial epithelial cells in 2D and 3D cultural conditions

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  The experiment is part of a project to study DNA repair process after ionizing radiation in organotypic 3-dimentional human bronchial epithlial cell culture. Human...

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• Proton irradiation augments the reduction in tumor progression observed with advanced age

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  Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have...

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